Selectins and their involvement in the pathogenesis of cardiovascular diseases

The review presents current data on the structure and functional role of cell adhesion molecules belonging to selectin family (selectins P, L E), their involvement in pathogenesis cardiovascular diseases. On one hand, intercellular vascular wall endothelium, platelets leukocytes are an important link processes vasculogenesis, development regeneration system. other these participate earliest stages endothelial dysfunction with subsequent pathology. For this reason, figuring out mechanisms activity group is very for understanding molecular basis diseases pathogenesis. molecules, both between cells a component extracellular matrix, most stage physiological biochemical processes. According present knowledge, five classes known: integrins, cadherins, immunoglobulins (including nectins), selectins addressins. All them bonded cytoplasmic membrane provide interaction each other. Some transmembrane associated cytoskeleton cell. surface, can be located clusters, forming multipoint binding sites thereby determining degree avidity. One significant functions participation initial leukocyte cascade, which results rolling further extravasation into tissues. first process mediated by specific non-covalent interactions glycan ligands, glycans functioning as interface or cancer endothelium. Targeting remains main strategies aimed at developing new methods treating immune, inflammatory oncological